Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

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Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.

UNLABELLED NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an NrasQ61R knock-in allele to similarly designed KrasG12D and NrasG12D alleles. With concomitant p16INK4a inactivation, KrasG12D or NrasQ61R expression efficiently promoted melanoma in vivo, whe...

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NRAS Codon 61 Selection in Melanoma

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ژورنال

عنوان ژورنال: Cancer Discovery

سال: 2014

ISSN: 2159-8274,2159-8290

DOI: 10.1158/2159-8290.cd-14-0729